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- I't's a remake of the Swedish tv-series Real Humans (Äkta människor).
- On the Persona Synthetics website, Sally is listed as a model PS Lundstrom S6-XI. Lars Lundström is the creator of the TV series Äkta människor of which Humans is an adaption.
- William Hurt was also in A.I. Artificial Intelligence (2001) which he played the creator of androids which serve humans.
- Silas Capek is a reference to Karel Capek, the writer of the play R.U.R (Rossum's Universal Robots) he is also the creator of the term Robot which derives from the word Robota, a word that in his native language (Czech) means "work".
- Gemma Chan, Tom Goodman-Hill, and Colin Morgan have all appeared in Doctor Who.
- Gemma Chan and Katherine Parkinson both have appeared in the TV series Sherlock.
- Gemma Chan and Katherine Parkinson appeared in the TV sitcom The IT Crowd.